BIOP 8020 - Advanced Protein Crystallography

An in-depth assessment of the current methodology in macromolecular crystallography. In addition to formal lectures, a number of hands-on sessions introduce students to experimental aspects of crystallization and sample preparation, data collection, as well as selected problems in computing. The lectures cover selected aspects of crystal symmetry, diffraction theory including diffraction by helical structures and fiber diffraction, methods of data collection and structure solution, with emphasis on the contemporary approaches utilizing synchrotron radiation and exploiting anomalous scattering. Refinement and model assessment and selected papers are discussed.

Credits: 3