CHEM 8450 - Enzymatic Reaction Mechanisms

Studies the mechanisms of enzymatic catalysis of organic reactions, emphasizing the transformation of substrates to products rather than focusing on protein chemistry. Includes the application of physical organic techniques to the study of enzymatic reactions. Major reaction types considered include hydrolases, group transfer reactions, coenzyme-catalyzed reactions, biological redox reactions, eliminations, racemizations, and aldol cleavage reactions. Considers the regulation of enzymatic activity and the validity of current techniques of investigating enzyme catalysis. Prerequisite: Instructor permission.

Credits: 3